Global Disease

With one of these, it's really possible for Exactly 8.3 Million people to come down with it at some point in time.

The contagious illness that's either spread around the world or is in the process of global infection. When a Global Disease is let loose on the world, it's time for someone to find the Vital Cure to Save The World from global death. As they're going on their journey to Save The World, they may meet people who are being infected by the Global Disease and need to be helped immediately. Bonus Points if somebody pulls a Not Really Okay trick on our heroes and endanger the group of Saviors.